En
  • دکتری (1368)

    بیو شیمی

    بمبئی، هندوستان

  • دکتری (1368)

    بیوشیمی (ملکولی)

    گرانت مدیکال کالج-دانشگاه بمبئئ، بمبئی - دهلی، هند

  • کارشناسی‌ارشد (1364)

    بیو شیمی

    گرانت مدیکال کالج-بمبیی، هندوستان

  • کارشناسی (1362)

    میکروبیولوژی

    هند، کلاپور، هندوستان

  • عوامل سرطانزا و سرطانزایی
  • بیومارکرهای سرطان
  • سلولهای بنیادی بالغ:بیوشیمی و بیولوژی ملکولی
  • بیولوژی ملکولی
  • کشت سلول های بنیادی بالغ

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ارتباط

رزومه

Methylation of TGM-3 Promoter and Its Association with Oral Squamous Cell Carcinoma (OSCC)

Sorour Shojaeian, Abdolkarim Moazeni-Roodi, Abdolamir Allameh, Ata Garajei, Anoshirvan Kazemnejad, Kourosh Kabir, Amir-Hassan Zarnani
Journal PapersAvicenna Journal of Medical Biotechnology , Volume 13 , Issue 2, 2021 March 1, {Pages 65-73 }

Abstract

Background: Oral Squamous Cell Carcinoma (OSCC) is among the ten most common cancers worldwide. Hypermethylation of CpG sites in the promoter region and subsequent down-regulation of a tumor suppressor gene, TGM-3 has been proposed to be linked to different types of human cancers including OSCC. In this study, methylation status of CpG sites in the promoter region of TGM-3 has been evaluated in a cohort of patients with OSCC compared to normal controls.Methods: Forty fresh tissue samples were obtained from newly diagnosed OSCC patients and normal individuals referred to dentistry clinic for tooth extraction. DNA was extracted, bisulfite conversion was performed and it was subjected to PCR using bisulfite-sequencing PCR (BSP) primers. Prepar

Immobilization of Candida rugosa lipase for resolution of racimic ibuprofen

Saeid Ghofrani, Abdolamir Allameh, Parichehreh Yaghmaei, Dariush Norouzian
Journal PapersDARU Journal of Pharmaceutical Sciences , 2021 February 2, {Pages 07-Jan }

Abstract

AimDue to lipases’ regio-selectivity and ability to catalyze different reactions such as hydrolysis, esterification, and transesterification, the enzyme is attractive in biotransformation technology. Besides, another technology, namely enzyme immobilization, has attracted scientists/technologists’ attention to employ immobilized lipase in such a field. Thus lipase of Candida rugosa was immobilized onto silica nanoparticles through adsorption. Furthermore, the immobilized biocatalyst was characterized and used to esterify ibuprofen enantioselectively.MethodsTo characterize immobilized lipase onto silica nanoparticles scanning electron microscopy (SEM) and dynamic light scattering (DLS) were used.ResultsThe catalytic properties of both im

Treatment of diabetic mice by microfluidic system-assisted transplantation of stem cells-derived insulin-producing cells transduced with miRNA

Adele Soltani, Masoud Soleimani, Mohammad Adel Ghiass, Seyed Ehsan Enderami, Shahram Rabbani, Arefeh Jafarian, Abdolamir Allameh
Journal PapersLife Sciences , 2021 March 11, {Pages 119338 }

Abstract

AimsCell-based therapy is a promising approach for the treatment of type-1 diabetes mellitus. Identifying stem cells with differentiation potential to Insulin-producing cells (IPCs) and their application is an emerging issue. Different strategies have been used to support cell survival and their specific functions to control hyperglycemia conditions. Novel technologies using appropriate materials/fibers can improve cell transplantation.Main methodsIn the present study, IPCs were differentiated from adipose-derived stem cells transduced with miR-375 and anti-miR-7. The cells' survival rate was also improved using a microfluidic system before their in vivo transplantation.Key findingsAfter adopting a stable, functional condition of the IPCs,

Diagnostic value of chronic inflammatory factors in non-muscle invasive bladder cancer.

Nazi Aghaalikhani, Nadereh Rashtchizadeh, Pejman Shadpour, Abdolamir Allameh, Marzieh Mahmoodi
Journal PapersCrescent Journal of Medical and Biological Sciences , Volume 8 , Issue 1, 2021 January , {Pages 42-47 }

Abstract

see more details (BC) probably depend on the stages and grades of tumors. The aim of this research was to find out if there is a relationship between the serum levels of selected inflammatory factors and the pathological grades/stages of tumors in new cases of non-muscle invasive urothelial bladder carcinoma carcinoma Subject Category: Diseases, Disorders, and Symptomssee more details patients. Materials and Methods: Blood samples were collected from 40 newly diagnosed non-muscle invasive urothelial bladder carcinoma patients (before the surgery surgery Subject Category: Disciplines, Occupations and Industries

Hepatoprotective effects of Lactobacillus plantarum 299v supplemented via drinking water against aflatoxin-induced liver damage

A Allameh, M Khanian, MA Karimi-Torshizi, A Kalantari-Hesari
Journal Papers , , {Pages }

Abstract

Diagnostic Value of Chronic Inflammatory Factors in Non-muscle Invasive Bladder Cancer

N Aghaalikhani, N Rashtchizadeh, P Shadpour, A Allameh, M Mahmoodi
Journal Papers , , {Pages }

Abstract

Glutathione-related inflammatory signature in hepatocytes differentiated from the progenitor mesenchymal stem cells

Abdolamir Allameh, Hamid Reza Ahmadi-Ashtiani, Narges Maleki
Journal PapersHeliyon , Volume 6 , Issue 6, 2020 June 1, {Pages e04149 }

Abstract

N-acetylcysteine (NAC) as a glutathione inducer is known for its anti-inflammatory effects in inflammatory conditions. The aim of the present study was to know if supplementation of the culture medium with NAC can improve anti-inflammatory activities of hepatocytes during their differentiation from mesenchymal stem cells (MSCs). For this, in vitro hepatic differentiation of MSCs was performed in culture medium supplemented with NAC and selected pro- and anti-inflammatory factors were monitored for two weeks. Treatment of the MSCs undergoing hepatic differentiation with NAC (0.1 and 1.0 mM) caused a significant (~5-fold) increase in proliferation rate of MSCs, whereas the rate of hepatic differentiation was declined in NAC-treated cells as c

Involvement of haptoglobin phenotypes and genotypes in non-muscle invasive bladder cancer: A possible prognostic marker for risk stratification

Nazi Aghaalikhani, Mojtaba Zamani, Abdolamir Allameh, Amir Mashayekhi, Pejman Shadpour, Marzieh Mahmoodi, Nadereh Rashtchizadeh
Journal PapersEXCLI journal , Volume 19 , 2020 January , {Pages 351 }

Abstract

The association of haptoglobin (Hp) with various cancers has been reported and also it has been documented that the Hp phenotypes/genotypes have different functional ability. So, we examined phenotypes/genotypes of Hp in newly diagnosed, untreated non-muscle invasive bladder cancer (NMIBC) patients and investigated its prognostic value for risk stratification of the cancer. In eighty NMIBC patients and 80 healthy individuals the Hp genotypes and phenotypes were analyzed using polymerase chain reaction (PCR) and two-dimensional gel electrophoresis (2D-GE), respectively. Besides, the presence of the Hpα1, α2, and β chains in the sera was confirmed by Mass Spectrometry (MS). The frequencies of the 1-1 and 2-2 genotypes/phenotypes were respe

Novel Formulation for Recombinant Streptokinase by Solid Lipid Nanoparticle: A Light at the End of the Tunnel

Hediyeh Rassam, Abdolamir Allameh, Akram Eidi, Mahmoud Alebouyeh, Delaram Doroud
Journal PapersArchives of Pharmacy Practice , Volume 1 , 2020 January , {Pages 149 }

Abstract

Anticoagulants are used to prevent or treat thrombotic diseases. Some antithrombotic drugs like streptokinase (SK) are ones that cause destruction of the clot or thrombosis through fibrinolytic system. These drugs imitate the action of the plasminogen activator enzyme in the body. In this research, we have investigated the potential of solid lipid nanoparticles (SLNs) as the carrier of proteins of thrombolytic factors. The SLNs formula has been developed for use in targeted enzymatic delivery of recombinant streptokinase (rSK) using a combined technique. Response surface method (RSM) has been used to provide the best formula and to analyze the effect of different parameters on the efficiency of the SLN-rSK formula. According to the results

Induced Hyperglycemia in Mice is Controlled Following the Microfluidic System-Assisted Transplantation of Stem Cells-derived Insulin-producing Cells Transduced with miRNA

Adele Soltani, Masoud Soleimani, Mohammad Adel Ghiass, Seyed Ehsan Enderami, Shahram Rabbani, Arefeh Jafarian, Abdolamir Allameh
Journal Papers , 2020 September 18, {Pages }

Abstract

BackgroundCell-based therapy is a promising approach for the treatment of type 1 diabetes mellitus. Identi cation of stem cells as progenitor stem cells with differentiation potential to Insulin-producing cells (IPCs) and their application is an emerging issue. Different strategies have been used to support the cell survival and their speci c functions to control hyperglycemia condition. Novel technology systems using appropriate materials/bres can improve the cell transplantation.

Expression levels of plasma exosomal miR-124, miR-125b, miR-133b, miR-130a and miR-125b-1-3p in severe asthma patients and normal individuals with emphasis on inflammatory factors

Mostafa Atashbasteh, Esmaeil Mortaz, Seyed Alireza Mahdaviani, Hamidreza Jamaati, Abdolamir Allameh
Journal Papers , 2020 December 4, {Pages }

Abstract

BackgroundIdenti cation of molecular markers, such as miRNAs is promising for the diagnosis of asthma and its clinical phenotypes. The aim of this study was to examine the changes in the expression of selected microRNAs in plasma exosomal fractions severe asthma patients. The expression of the miRNAs was determined in relation to the changes in serum immuno-in ammatory markers.

Role of the mesenchymal stem cells derived from adipose tissue in changing the rate of breast cancer cell proliferation and autophagy, in vitro and in vivo

Maryam Adelipour, Abdolamir Allameh, Abdolkarim Sheikhi, Mina Ranjbaran, Mahshid Naghashpour, Zahra Nazeri, Hoda Mojiri-Foroshani, Sahar Golabi
Journal PapersIranian Journal of Basic Medical Sciences , 2020 November 24, {Pages }

Abstract

Objective(s): Autophagy is an intracellular degradation system of damaged proteins and organelles; however, the role of autophagy in the progression of cancer remains unclear. In recent years, mesenchymal stem cell (MSC)-based approaches have attracted considerable attention for anti-cancer therapy. The present study aimed to examine the interaction of MSCs with the breast cancer cells under autophagy-induced conditions. Materials and Methods: In this study, MSCs isolated from human adipose tissue were co-cultured with MDA-MB 231, a breast cancer cell line, and the autophagy process was induced by tunicamycin treatment. The cell viability was monitored by the MTT assay, and the cells were recovered at different time intervals (24 or 48 hour

The predominant microRNAs in β-cell clusters for insulin regulation and diabetic control

A Soltani, A Jafarian, A Allameh
Journal Papers , , {Pages }

Abstract

Alleviation of aflatoxin-related oxidative damage to liver and improvement of growth performance in broiler chickens consumed Lactobacillus plantarum 299v for entire growth period

Maryam Khanian, Mohammad-Amir Karimi-Torshizi, Abdolamir Allameh
Journal PapersToxicon , Volume 158 , 2019 February 1, {Pages 57-62 }

Abstract

Growing broiler chicks on a diet contaminated with aflatoxins (200 or 2000 ppb) for entire growth period resulted in increased oxidative stress and liver damage markers. The toxicity was subsided in broilers received a specific aflatoxin-binding probiotic i.e., Lactobacillus plantarum 299v (Lp299v). There was a substantial (30–90%) increase in antioxidant activity of plasma, which was suppressed due to dietary aflatoxins. Probiotic also reduced serum lactate dehydrogenase and alanine amino transferase together with lipid peroxidation products in liver, which were elevated due to aflatoxin. Because of Lp299v consumption, there was ∼20–55% recovery in body weight gain in broilers intoxicated with aflatoxins. Comparison of the Lp299v e

Effects of zinc supplementation on superoxide dismutase activity and gene expression, and metabolic parameters in overweight type 2 diabetes patients: A randomized, double?…

Mohammad Reza Nazem, Mojgan Asadi, Niloofar Jabbari, Abdolamir Allameh
Journal PapersClinical biochemistry , Volume 69 , 2019 July 1, {Pages 15-20 }

Abstract

ObjectiveDespite the current guidelines for the management of type 2 diabetes mellitus (T2DM), patients still struggle with the hyperglycemia consequences. Imbalance in zinc homeostasis, in particular, renders diabetic patients more susceptible to the damages of oxidative stress. This study aimed to evaluate the effects of zinc supplementation on the superoxide dismutase gene expression and enzyme activity in overweight individuals with T2DM. Additionally, biochemical parameters, such as fasting blood glucose (FBG), insulin, glycated hemoglobin (HbA1c), homeostasis model of assessment-insulin resistance (HOMA-IR), serum levels of zinc and lipid profile, were assessed.MethodsIn this randomized, double-blind, placebo-controlled trial, 70 over

Cancer stem cells as a therapeutic target in bladder cancer

Nazi Aghaalikhani, Nadereh Rashtchizadeh, Pejman Shadpour, Abdolamir Allameh, Marzieh Mahmoodi
Journal PapersJournal of cellular physiology , Volume 234 , Issue 4, 2019 April , {Pages 3197-3206 }

Abstract

Bladder cancer is one of the most prevalent genitourinary cancers responsible for about 150,000 deaths per year worldwide. Currently, several treatments, such as endoscopic and open surgery, appended by local or systemic immunotherapy, chemotherapy, and radiotherapy are used to treat this malignancy. However, the differences in treatment outcome among patients suffering from bladder cancer are considered as one of the important challenges. In recent years, cancer stem cells, representing a population of undifferentiated cells with stem‐cell like properties, have been eyed as a major culprit for the high recurrence rate in superficial papillary bladder cancer. Cancer stem cells have been reported to be resistant to conventional treatments

Differential expression of S1P receptor subtypes in human bladder transitional cell carcinoma

A Palangi, N Shakhssalim, M Parvin, S Bayat, A Allameh
Journal PapersClinical and Translational Oncology , 2019 February 2, {Pages 10-Jan }

Abstract

PurposeSphingosine 1 phosphate (S1P), S1P receptors (S1PRs) and their signaling pathways play an important role in the fate of cancer cells. The expression pattern of S1PR subtypes (S1PR1–S1PR5) may alter in cancer development stages, depending on the origin and the pathologic features of tumors. The present study aimed to examine the relationship between plasma S1P levels and the expression of S1PR subtypes in bladder tumors.

Effects of concomitant exposure to styrene and intense noise on rats’ whole lung tissues. Biochemical and histopathological studies

Mojtaba Haghighat, Abdolamir Allameh, Mohammad Fereidan, Ali Khavanin, Zahrasadat Ghasemi
Journal PapersDrug and Chemical Toxicology , 2019 October 1, {Pages 07-Jan }

Abstract

Concurrent exposure to styrene (ST) and noise is common especially in industrial environments. The present study aims to determine the related oxidant-induced changes as the result of combined exposure to ST and noise. For this purpose, 24 male Wistar rats were used in four experimental groups (n = 6/groups): (1) control group, (2) the group exposed to an octave band of noise centered at 8 kHz (100 dB SPL) (6 h/day), (3) the group inhalationally exposed to ST (750 ppm) (6 h/day), (4) the group exposed to noise and ST simultaneously. The DNA damage was measured by assessing the concentration of 8-hydroxyl-2-deoxyguanosine (8-OHdG) using ELISA kit. Levels of lipid peroxidation (MDA), GSH and antioxidative activity of SOD and CAT

Increased expression of Klotho occurs without changes in CYP27B1 and 1, 25 dihydroxyvitamin D-3 levels in the spinal cord of mice with experimental autoimmune encephalomyelitis

MS Aleagha, A Allameh, M Pahlevan-Kakhki, MH Harirchian
Conference PapersMULTIPLE SCLEROSIS JOURNAL , Volume 25 , 2019 September 1, {Pages 654-654 }

Abstract

In Vitro Anti-Mycotoxigenic and Anti-Aflatoxigenic Properties of Probiotic Bacteria; Lactobacillus plantarum and L. paracasei

Abdolamir Allameh, F Ani, M Shams-Ghahfarokhi, M Razzaghi-Abyaneh
Journal PapersJournal of Sciences, Islamic Republic of Iran , Volume 30 , Issue 4, 2019 November 1, {Pages 305-313 }

Abstract

The present study was designed to examine the effects of Lactobacillus plantaraum and L. paracasei on the growth and aflatoxin-producing ability of Aspergillus parasiticus. In these experiments, direct and indirect interactions of two different probiotic lactobacilli with A. parasiticus was examined. A co-culture system which supported both fungal growth and probiotic bacteria showed the inhibitory actions of the lactobacilli on A. parasiticus growth. Disk Diffusion Assay was developed to examine the anti-fungal action of the probiotic cell free extract. The probiotic extracts were also applied in a micro-dilution assay to evaluate the anti-fungal and anti-aflatoxin properties of the probiotic extracts. The results showed that direct intera

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دروس نیمسال جاری

  • دكتري
    بيوشيمي سرطان و تومور ماركرها ( واحد)
    دانشکده علوم پزشکی، گروه بيو شيمي پزشكي
  • كارشناسي ارشد
    بيوشيمي و تشخيص مولكولي ( واحد)

دروس نیمسال قبل

  • كارشناسي ارشد
    روشهاي آزمايشگاهي ، شناخت و كار با دستگاهها ( واحد)
    دانشکده علوم پزشکی، گروه بيو شيمي پزشكي
  • كارشناسي ارشد
    روشهاي آزمايشگاهي ، شناخت و كار با دستگاهها ( واحد)
  • كارشناسي ارشد
    بيوشيمي پيشرفته بافتها ( واحد)
  • دكتري
    بيوشيمي سرطان و تومور ماركرها ( واحد)
  • 1400
    زارع مهرجردي, محمد جليل
    مطالعه تغييرات بيان H-ras در روند تغييرات سرطان اوليه كبد القا شده در مدل موشي با عامل دي اتيل نيتروزآمين و فنوباربيتال
  • 1395
    رضاپور كلخوران, مريم
    ارزيابي تاثير پيوند سلول هاي بنيادي مزانشيمي مشتق از بافت چربي انساني حامل ژن كلوتو بر شاخص هاي تمايز و بلوغ اليگودندروسيت ها در سيستم عصبي مركزي موش مدل تجربي انسفالوميليت اتوايميون (EAE)
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    ملكي, نرگس
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    دايتي, پريسا
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    اماميان, مرضيه
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    نيايش مهر, ريحانه
  • 1399
    جعفري خورچاني, مجيد
  • رئیس دانشکده علوم پزشکی
  • مدیر گروه بیوشیمی بالینی-تربیت مدرس
  • عضو هییت ممیزه دانشگاه تربیت مدرس
  • عضو هییت ممیزه دانشگاه گیلان
  • عضو هییت ممیزه پژوهشگاه ملی مهندسی ژنتیک و پژوهشگاه شیمی و مهندسی شیمی
  • عضو هییت امنا پارک علم و فناوری پردیس
  • عضو انجمن تحقیقات سرطان آمریکا
  • عضو هییت تحریریه مجله بیوشیمی کلینکال- الزیور
  • استاد نمونه دانشگاه تربیت مدرس
  • برنده تالیف بهترین کتاب بیستمین دوره انتخاب کتاب سال جمهوری اسلامی ایران-1382
  • رتبه دوم علوم پایه پزشکی یازدهمین جشنواره علوم پزشکی رازی
  • مولف کتاب بیوشیمی سرطان
  • مولف کتاب بیوشیمی سرطان
  • مولف کتاب بیوشیمی سرطان
  • مولف کتاب بیوشیمی سرطان
  • مولف کتاب بیوشیمی سرطان
  • مولف کتاب بیوشیمی سرطان 1399
  • مولف کتاب بیوشیمی سرطان 1399

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