En
  • دکتری (1382)

    تربیت مدرس، تهران، ایران

  • کارشناسی‌ارشد (1373)

    ویروس شناسی پزشکی

    دانشگاه تربیت مدرس، تهران، ایران

  • کارشناسی (1363)

    علوم آزمایشگاهی

    دانشگاه علوم پزشکی تبریز، تبریز، ایران

  • بکارگیری ویروسهای اونکولایتیک در درمان سرطان
  • روشهای نوین مولكولی در تشخیص بیماریهای ویروسی
  • استفاده از سلولهای بنیادی بعنوان حامل ویروسهای اونکولایتیک
  • فناوری های جدید در پیشگیری و تولید واكسن و ارتقاء سلامت

    حوریه سلیمان جاهی متولد 1339 درمرند بدنیا آمد. مقطع كارشناسى را در رشته علوم آزمایشگاهی در دانشگاه علوم پزشکی تبریز به اتمام رساند. پس از آن مدرک کارشناسی ارشد را در سال 1373 در دانشکده علوم پزشكى تربیت مدرس دریافت کرد. از سال 1373 بعد از اتمام کارشناسی ارشد بمدت سه سال در دانشگاه بعنوان عضو هیات علمی فعالیت داشتند تا در سال 1377 بعنوان دانشجوی رتبه اول در کنکور دکترای تخصصی ویروس شناسی قبول شدند و در سال 1382 موفق به اخذ دکترای تخصصی ویروس شناسی در تربیت مدرس شدند. بلافاصله بعد از فارغ التحصیلی بعلت سابقه کاری پیشین در دانشگاه از سال 1382 مشغول به کار شدند و ا کنون در گروه ویروس شناسی دانشگاه تربیت مدرس بعنوان مدیرگروه مشغول به کار می باشند. ایشان از سال 1396عضو بورد ویروس شناسی ، عضو هیات مدیره انجمن ویروس شناسی ، جامعه علمی آزمایشگاهیان ایران ، عضو شورای نظارت دانشکده و سردبیر مجله AMLS می باشند. ایشان در زمینه اونکولایتیک ویروسها و بهینه سازی واکسنهای نوترکیب و استفاده از سلولهای بنیادی بعنوان حامل فعالیت دارند.

    Importance of SARA-COV-2 serological tests in diagnosis, vaccination and treatment

    Hoorieh Soleimanjahi
    Journal PapersPathobiology Research , Volume 24 , Issue 1, 2021 March 10, {Pages 89-97 }

    Abstract

    SARS-COV-2, the latest member of Coronaviridea family as the cause of the recent global epidemic, has inflicted sever damages in different fields on most governments. Appropriate strategies such as identifying infected individuals and isolating them, trying to produce an effective vaccine, finding efficient treatment and making correct decisions in the social, economic and health fields are the current priorities of the world. Simultaneous serological tests with molecular tests have led to a reduction in false-negative cases of these tests, which leads to the timely isolation of more patients and less spread of the disease. Evaluation of humoral immune responses by serological tests contribute to effective vaccine production. Serological te

    Frequency of Cytomegalovirus Viral Load in Iranian Human Immunodeficiency Virus-1-Infected Patients with CD4+ Counts< 100 Cells/mm3

    Mohammad Reza Jabbari, Hoorieh Soleimanjahi, Somayeh Shatizadeh Malekshahi, Mohammad Gholami, Leila Sadeghi, Minoo Mohraz
    Journal PapersIntervirology , 2021 March 31, {Pages 05-Jan }

    Abstract

    Objectives: The aim of present work was to assess cytomegalovirus (CMV) viremia in Iranian human immunodeficiency virus (HIV)-1-infected patients with a CD4+ count< 100 cells/mm 3 and to explore whether CMV DNA loads correlate with CD4+ cell counts or associated retinitis. Methods: This study was conducted at the AIDS research center in Iran on HIV-1-infected patients with CD4+ count< 100 cells/mm 3, antiretroviral therapy-naive, aged≥ 18 years with no previous history of CMV end-organ disease (CMV-EOD). Results: Thirty-nine of 82 patients (47.56%) had detectable CMV viral load ranging from 66 to 485,500 IU/mL. CMV viral load in patients with retinitis ranges from 352 to 2,720 IU/mL, and it was undetectable in 2 patients. No significant a

    Evaluation of Mutation Spread in The SARS-CoV2 Genome

    Kamal Fakhredini, Hooreih Soleimanjahi, Razieh Sadat Banijamali, Taravat Bamdad
    Journal PapersPathobiology Research , Volume 24 , Issue 1, 2021 March 10, {Pages 41-49 }

    Abstract

    The Coronaviridae family includes viruses that are considered the causative agents of respiratory infections, and among human RNA viruses have the largest genome. Coronaviruses undergo elusive genetic changes through mutation during replication. A gene mutation is a permanent alteration in the nucleic acid sequence; if it occurs in large numbers, it causes changes in the biological features of a species. Fundamentally, viruses adapt to the human body during replication. Several studies have shown that most mutations do not have much effect on pathogenicity. Sequence diversity in new coronaviruses is very low. However, antigen drift has been observed among some coronaviruses. Most coronavirus mutations occur intermittently in Iran and other

    MSCs loaded with oncolytic reovirus: migration and in vivo virus delivery potential for evaluating anti-cancer effect in tumor-bearing C57BL/6 mice

    Seyed-Mahmood Seyed-Khorrami, Hoorieh Soleimanjahi, Sara Soudi, Ala Habibian
    Journal PapersCancer Cell International , Volume 21 , Issue 1, 2021 December , {Pages 19-Jan }

    Abstract

    Several oncolytic viruses applications have been approved in the clinic or in different phases of clinical trials. However, these methods have some rudimentary problems. Therefore, to enhance the delivery and quality of treatment, considering the advantage of cell carrier-based methods such as Mesenchymal Stem Cells (MSC) have been proposed. This study was designed to evaluate the performance and quality of cancer treatment based on MSCs loaded by oncolytic reovirus in the cancerous C57BL/6 mouse model. Also, we evaluated MSCs migration potency in vitro and in vivo following the oncolytic reovirus infection. C57BL/6 mice were inoculated with TC-1 cell lines and tumors were established in the right flank. Mice were systemically treated with

    Low-intensity ultrasound as a novel strategy to improve the cytotoxic effect of oncolytic reovirus on colorectal cancer model cells

    N Sharifi, H Soleimanjahi, M Mokhtari-Dizaji, RS Banijamali, ...
    Journal Papers , , {Pages }

    Abstract

    Mesenchymal stem cells loaded with oncolytic reovirus enhances antitumor activity in mice models of colorectal cancer

    A Babaei, H Soleimanjahi, M Soleimani, E Arefian
    Journal Papers , , {Pages }

    Abstract

    Mesenchymal stem cells support delivery and boost the efficacy of oncolytic reoviruses in TC‐1 tumor cells

    RS Banijamali, H Soleimanjahi, S Soudi, H Karimi
    Journal Papers , , {Pages }

    Abstract

    Comparison of the Effect of Adipose Mesenchymal Stem Cells-derived Secretome with and without Reovirus in CT26 Cells

    A Rezazadeh, H Soleimanjahi, S Soudi, A Habibian
    Journal Papers , , {Pages }

    Abstract

    Reovirus and Rotaviruses: Basic General, Molecular, Clinical, and Application Features

    H Soleimanjahi, FH Heydarabadi
    Journal Papers , , {Pages }

    Abstract

    Papillomaviruses: Basic General, Molecular, Clinical and Immune Evasion Mechanisms

    H Soleimanjahi, A Habibian
    Journal Papers , , {Pages }

    Abstract

    SARS-CoV-2 seroprevalence in asymptomatic or mild symptomatic people and symptomatic patients with negative PCR results: The hidden perspective in epidemiological reports

    N Hajiahmadi, A Yari, M Tat, H Soleimanjahi, SA Jamehdar, M Jafari, ...
    Journal Papers , , {Pages }

    Abstract

    Importance of SARA-COV-2 serological tests in diagnosis, vaccine productin and treatment

    N Hajiahmadi, H Soleimanjahi, T Bamdad
    Journal Papers , , {Pages }

    Abstract

    Kinetics of Oncolytic Reovirus T3D Replication and Growth Pattern in Mesenchymal Stem Cells

    Razieh Sadat Banijamali, Hoorieh Soleimanjahi, Sara Soudi, Hesam Karimi, Asghar Abdoli, Seyed Mahmood Seyed Khorrami, Keivan Zandi
    Journal PapersCell journal , Volume 22 , Issue 3, 2020 October , {Pages 283 }

    Abstract

    Objective: Currently, application of oncolytic-virus in cancer treatment of clinical trials are growing. Oncolytic-reovirus is an attractive anti-cancer therapeutic agent for clinical testing. Many studies used mesenchymal stem cells (MSCs) as a carrier cell to enhance the delivery and quality of treatment with oncolytic-virotherapy. But, biosynthetic capacity and behavior of cells in response to viral infections are different. The infecting process of reoviruses takes from two-hours to one-week, depends on host cell and the duration of different stages of virus replication cycle. The latter includes the binding of virus particle, entry, uncoating, assembly and release of progeny-viruses. We evaluated the timing and infection cycle of reovi

    The Convenient and Economical Method to Collect Adipose Mesenchymal Stem Cells

    Hoorieh Soleimanjahi
    Journal PapersArchives of Medical Laboratory Sciences , Volume 5 , Issue 1, 2020 May 3, {Pages }

    Abstract

    Background: Enzymatic digestion is an essential stage for culturing Mesenchymal Stem Cells (MSCs) and their therapeutic application. Several factors such as being cost-benefit, efficiency, safety, yield and amount of produced cells are determinant for choosing the appropriate enzyme. Collagenase is a conventional enzyme commonly used for enzymatic digestion. However, other enzymes like trypsin and even combination of these enzymes can be used as an alternative strategy in different situations.Materials and Methods: Abdominal subcutaneous adipose tissue was obtained from male BALB/c mice and digested under three different enzymatic processes: collagenase and collagenase/trypsin and trypsin. Cell culture process was performed under standard c

    combination therapy using human papillomavirus L1/E6/E7 genes and archaeosome: a nanovaccine confer immuneadjuvanting effects to fight cervical cancer

    Hesam Karimi, Hoorieh Soleimanjahi, Asghar Abdoli, Razieh Sadat Banijamali
    Journal PapersScientific reports , Volume 10 , Issue 1, 2020 April 1, {Pages 15-Jan }

    Abstract

    Cancer is a leading cause of death worldwide. Cervical cancer caused by human papillomavirus (HPV) is a major health problem in women. DNA vaccines are a perfect approach to immunization, but their potency in clinical trials has been insufficient for generating effective immunity, which may be related to the degradation of the DNA via nucleases, poor delivery to antigen-presenting cells (APCs), and insufficient uptake of DNA plasmids by cells upon injection. Archaeosome is a nano-delivery systems based on liposomes with their immunological role have been developed for gene delivery. In this study, human papillomavirus type 16 genes, containing truncated L1, E6, and E7, were simultaneously used in combination therapy with archaeosome and ass

    The synergistic anticancer effects of ReoT3D, CPT-11, and BBI608 on murine colorectal cancer cells

    Abouzar Babaei, Hoorieh Soleimanjahi, Masoud Soleimani, Ehsan Arefian
    Journal PapersDARU Journal of Pharmaceutical Sciences , 2020 August 15, {Pages 11-Jan }

    Abstract

    BackgroundMany types of oncolytic viruses (OVs) were enrolled in clinical trials. Recently, an OV named Talimogene laherparepvec approved for the treatment of melanoma. This achievement highlighted the clinical application of OVs. Scientists focus on using these anticancer agents in combination with the current or/and new anticancer chemotherapeutics. They aim to increase the oncolytic effect of a new approach for the treatment of cancer cells.ObjectivesThe present study aimed to assess the anticancer impacts of ReoT3D, irinotecan (CPT-11), and napabucasin (BBI608) against murine colorectal cancer cells (CT26). They are assessed alone and in combination with each other.MethodsHere, oncolytic reovirus was propagated and titrated. Then MTT as

    HSV-TK Expressing Mesenchymal Stem Cells Exert Inhibitory Effect on Cervical Cancer Model

    Azra Kenarkoohi, Taravat Bamdad, Masoud Soleimani, Hoorieh Soleimanjahi, Ali Fallah, Shahab Falahi
    Journal PapersInternational Journal of Molecular and Cellular Medicine , Volume 9 , Issue 2, 2020 January , {Pages 146 }

    Abstract

    A growing area of research is focused on cancer therapy, and new therapeutic approaches are welcomed. Mesenchymal stem cell (MSC)-based gene therapy is a promising strategy in oncology. Intrinsic tropism and migration to tumor microenvironment with off lights are attractive features of this type of cell carrier. In this way, suicide genes have also found a good platform for better performance and have shown a stronger anti-tumor mechanism by riding on mesenchymal cells. In this study, we investigated the anti-tumor activity of intratumoral injected MSCs transduced with a lentivector expressing the HSV/TK in a mouse cervical cancer model. Following the injection of MSCs transduced with lentivector carrying TK, MSCs alone or PBS into the mice

    The evaluation of viral fusion proteins structure and mechanism in different viruses

    Roya Kianfar, Hoorieh Soleimanjahi
    Journal PapersPathobiology Research , Volume 23 , Issue 3, 2020 July 10, {Pages 0-0 }

    Abstract

    Conclusion: The changes in fusion protein in the levels before and after fusion, description of fusion proteins in viruses such as Influenza, Filo, and Reoviruses as a prototype of fusion protein viruses and their therapeutic applications of fusion protein as a potential drugs such as Lactoferrin and Enfuvertide in preventing the occurrence of fusion phenomenon is important issue for consideration about multiplication and virus entry.

    Lack of human coronaviruses in patients with upper respiratory tract infections symptoms

    Somayeh Alipour, Hoorieh Soleimanjahi, Fatemeh Fotouhi
    Journal Papersمجله ویروس شناسی ایران , Volume 14 , Issue 1, 2020 June 10, {Pages 0-0 }

    Abstract

    OBJECTIVE: Coronaviridae family cause respiratory diseases ranging from common cold to severe Respiratory diseases such as SARS, MERS and new emerging coronavirus disease COVID-19. Also the family including four other human coronaviruses (HCoV-229E, HCoV-HKU1, HCoV-NL63, and HCoV-OC43) with flu likes symptoms. Coronaviruses cannot be distinguished clinically from other respiratory infectious agents. Based on the health importance and widespread distribution of respiratory infections, the current study was designed for diagnosis of Pancoronaviruses.MATERIALS AND METHODS: Nasopharyngeal swabs from 200 patient suspected viral upper respiratory tract infection analyzed using optimized RT-PCR assay. The constructive specific degenerate primers w

    Distribution of the most common types of HPV in Iranian women with and without cervical cancer

    Zohreh Farahmand, Hoorieh Soleimanjahi, Masoud Garshasbi, Malihe Hasanzadeh, Ehsan Zafari
    Journal PapersWomen & Health , 2020 September 23, {Pages 10-Jan }

    Abstract

    Cervical cancer is an important cause of death in women worldwide. About 99.7% of all cervical cancers have been related to human papillomavirus, especially types 16 and 18. Types 6 and 11 cause genital warts. We aimed to determine the prevalence of common HPV genotypes among women in the general population and women with cervical cancer. A total of 571 healthy women cytology specimens and 113 tissue samples of cervical cancer were investigated using HPV type-specific primers. HPV DNA was detected in 24% of healthy women: 3.3% were positive for high-risk HPV and 11.6% for low-risk HPV. HPV6 (9.3%) had the highest prevalence followed by HPV11 (2.3%), HPV16 (1.8%), HPV18 (1.2%), and 9.1% of samples were positive for unknown types

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    دروس نیمسال جاری

    • دكتري
      ويروس شناسي عملي 1 ( واحد)
      دانشکده علوم پزشکی، گروه ويروس شناسي
    • دكتري
      ويروس شناسي عمومي نوين ( واحد)
    • كارشناسي ارشد
      مباحث خاص در و يروس شناسي ( واحد)

    دروس نیمسال قبل

    • كارشناسي ارشد
      ويروس شناسي پزشكي ( واحد)
      دانشکده علوم پزشکی، گروه باكتري شناسي
    • كارشناسي ارشد
      ويروس شناسي سيستماتيك 2 ( واحد)
    • كارشناسي ارشد
      ويروس شناسي عمومي ( واحد)
    • كارشناسي ارشد
      ويروس شناسي عملي 1 ( واحد)
    • 1396
      رستگاروند, نسرين
      بررسي اثر microRNA مهار كننده ژن هاي سلولي EIF2AK2 و MAVS و تاثير آن در تكثير رئوويروس انكولايتيك
    • 1397
      كتابي, كيانا
    • 1397
      نصيري تاج ابادي, زينب
    • 1399
      عبدلي كولانكوه, محسن
    • 1400
      اقاميرمحمدعلي, فهيمه سادات
    • مدیر گروه ویروس شناسی
    • عضو هیات ممتحنه و بورد ویروس شناسی
    • سردبیر مجله Archive af Medical Labratory Sciences
    • عضو هیات تحریریه و ویراستار علمی مجله ویروس شناسی
    • عضو شورای نظارت دانشکده
    • عضو حقیقی کمیته فرهنگی دانشکده پزشکی
    • عضو کمیته تخصصی گروه قارچ شناسی پزشکی
    • عضو کمیته تخصصی گروه ایمنی شناسی
    • عضو کارگروه عفونی ، معاونت علمی و فناوری ریاست جمهوری
    • عضو گروه واژه گزینی میکروب شناسی بخش برون سپاری فرهنگستان زبان و ادب فارسی
    • عضو شورای بازنگری سرفصل دروس ویروس شناسی
    • عضو کمیته انکولیتیک ستاد توسعه زیست فناوری
    • اخذ لوح وجایزه در روز آزمایشگاهیان ایران
    • پژوهشگر برتر در چند مرحله در دانشگاه تربیت مدرس
    • مشاور پایان نامه خ فتوحی در اخذ رتبه دوم بخش محققین جوان در 4th جشنواره رازی
    • همکار اصلی دکتر روستائی در اخذ رتبه دوم در 4th جشنواره رازی

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